From Papyrus to EEG

I hope to examine how chronic war exposure, environmental neurotoxicants, and trauma-related stress may interact to affect stress regulation, brain health, and long-term mental health outcomes to create a more civilian-focused framework.

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My interest in cultural preservation and history also informed my capstone research on a Qur’an leaflet, which will be published as part of the Medieval Portland project. After graduation, I plan to attend medical school, with a specific interest in anesthesiology and patient advocacy.

LEARN MORE: Medieval Portland

“When was the brain first studied?”

I remember the question immediately catching my attention because it connected my love for neuroscience with my identity as someone from the Middle East. I felt a sense of pride thinking about the long scientific legacy of my region. I immediately thought of Ibn Al-Haitham, an Islamic Golden Age scholar who is considered to be the father of optics and despite it being my first outreach event and being relatively shy I was excited for the opportunity to teach about his legacy.

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The conversation surrounding the history of neuroscience usually traces back to ancient Greece before dramatically shifting toward Renaissance Europe and modern Western science. This narrative overlooks the immense medical and intellectual contributions outside of the Western sphere.

One such region that is overlooked is the Middle East, a region that has investigated the brain, consciousness, sensation, trauma, and even mental illness for thousands of years. Physicians and scholars throughout the region were already studying the field of neuroscience long before it existed as a formal academic discipline.

The history of neuroscience in the Middle East stretches from the surgical writings of ancient Egypt to the diagnostic systems of old Mesopotamia through the hospitals and scholars of the Golden Age of Islam. It’s a region of scholarly endeavors that continues to occupy a significant place in neuroscience even to this day, as well as experiencing the neurological and psychological consequences of war, from displacements to chronic stress and other traumas.

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Ancient Egypt

Map of Egypt

IMAGE SOURCE: Map of Ancient Egypt (Egypt Museum)

This papyrus is an ancient Egyptian medical manuscript dating to approximately 1600 BCE, and likely derived from even older sources from centuries earlier. Unlike many surviving medical writings from antiquity that focused heavily on spiritual healing, incantations, or magical intervention, the Edwin Smith Papyrus approached injury through structured clinical observation and practical medicine. Rather than attributing illness entirely to supernatural causes, Egyptian physicians carefully documented physical trauma and its physiological consequences in a manner that resembles early forms of clinical case analysis.

The papyrus contained approximately forty-eight documented injury cases, many involving severe trauma to the head, neck, and spine. Egyptian physicians described skull fractures, spinal injuries, speech impairment, paralysis, sensory dysfunction, seizures, and altered states of consciousness with remarkable detail for the time period. Each case typically followed a structured format involving examination, diagnosis, prognosis, and treatment recommendations. This organization resembles surprisingly early forms of medical charting and clinical reasoning still used in medicine today.

Although ancient Egyptian physicians possessed no understanding of neurons, cortical pathways, or modern neuroanatomy, these observations strongly resemble an early recognition of contralateral neurological control, one of the central organizational principles of the nervous system. The papyrus also included some of the earliest recorded descriptions of the meninges surrounding the brain, cranial sutures, and fluid leakage associated with traumatic head injury, likely corresponding to cerebrospinal fluid exposure following skull fractures.

Equally important is the manner in which these cases were documented. The physicians emphasized direct physical examination through observation, palpation, and symptom analysis rather than relying solely on “spiritual” interpretation.

IMAGE SOURCE: Edwin Smith Medical papyrus

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Cranial surgery: Different tools, similar question

Signs of bone healing around the openings indicate that some individuals survived long after the procedure, suggesting unexpectedly advanced surgical skill and postoperative care. Even when intertwined with spiritual or ritualistic beliefs, trepanation still reflects an emerging recognition that disorders involving consciousness, sensation, pain, or behavior were connected to the head itself. In this sense, ancient cranial surgery represents one of the earliest intersections between medicine, trauma care, and humanity’s developing understanding of the nervous system.

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Ancient Mesopotamia

IMAGE SOURCE: Ancient West Asia: cradle of civilization

The origins of neurological diagnostics can be traced back to Mesopotamian civilizations, where they developed highly organized systems of diagnosis and symptom classification. Babylonian and Assyrian physicians have documented conditions resembling epilepsy, paralysis, stroke, psychosis, and altered states of consciousness through cuneiform medical texts.

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The handbook reflected an increasingly sophisticated attempt to distinguish illnesses based upon observable physical and behavioral signs rather than viewing all disease as entirely unpredictable or mystical in nature. Physicians categorized symptoms, monitored disease progression, and attempted to predict outcomes based on prior cases and recognizable patterns. In many ways, this represented an early precursor to clinical neurology, where diagnosis depends heavily upon identifying consistent symptom presentations associated with specific neurological conditions.

Among the conditions receiving particular attention within Mesopotamian medicine was epilepsy. Seizures occupied a uniquely important place because they appeared deeply connected to consciousness, behavior, bodily control, and sudden alterations in awareness. To ancient observers, epilepsy could appear both physically dramatic and psychologically mysterious, making it one of the earliest neurological disorders to receive extensive documentation.

Mesopotamian physicians carefully described seizure activity, including convulsions, muscle rigidity, collapse, involuntary movements, vocalizations, altered awareness, confusion, and recurrence patterns. Some descriptions even appear to distinguish between different seizure presentations, suggesting an early recognition that epilepsy was not a single uniform condition but rather a collection of related neurological phenomena. Physicians also documented post-seizure confusion and behavioral changes, demonstrating attention to both the immediate and lingering effects of altered brain states.

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In many ways, Mesopotamian medicine established some of the earliest conceptual foundations for neurological diagnosis. Modern neurology still relies heavily upon observing behavioral changes, motor dysfunction, altered awareness, speech disturbances, and sensory abnormalities in order to identify disorders of the nervous system. Although separated by thousands of years and vastly different scientific frameworks, Mesopotamian physicians were already engaging in one of the most fundamental practices of neuroscience: carefully observing how changes within the body alter consciousness and behavior.

The significance of Mesopotamian medicine, therefore, extends beyond simple historical curiosity. These early diagnostic traditions demonstrate that humanity’s effort to systematically understand disorders of the brain and nervous system began far earlier than is often acknowledged. Even within societies deeply shaped by spiritual cosmologies, ancient physicians were laying the groundwork for clinical observation, neurological categorization, and the eventual emergence of neuroscience itself.

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Islamic Golden Age

LEARN MORE: The Islamic Golden Age: A Story of the Triumph of the Islamic Civilization

During this period, cities such as Baghdad, Damascus, Cairo, Córdoba, and Samarkand became major centers of scholarship where physicians, philosophers, mathematicians, and scientists worked across disciplines through interdisciplinary means, blending the different fields through Scientific inquiry that allows scholars to approach questions regarding consciousness, sensation, emotions, cognition, and diseases from multiple perspectives simultaneously.

At the center of this intellectual flourishing stood the House of Wisdom in Baghdad, founded during the Abbasid Caliphate. The House of Wisdom functioned as a research institute where scholars translated works from Greek, Persian, Indian, Egyptian, and Mesopotamian traditions into Arabic. Vast amounts of scientific and philosophical knowledge were preserved that may have otherwise been lost during periods of political upheaval in Europe and the Mediterranean.

Scholars of the Islamic Golden Age did far more than merely preserve earlier knowledge. Islamic scholars would often refine, critique, and also expanded on earlier medical theories through direct observation and experimentation. Medicine increasingly shifted toward systematic clinical practice while shifting away from purely philosophical speculation toward structured investigation grounded in patient observation, prognosis, and empirical reasoning.

“The doctor’s aim is to do good, even to our enemies, so much more to our friends, and my profession forbids us to do harm to our kindred, as it is instituted for the benefit and welfare of the human race, and God imposed on physicians the oath not to compose mortiferous remedies.” – Al-Razi

IMAGE SOURCE: Abu Bakr Muhammad Ibn Zakariya Al Razi (Rhazes): Philosopher, Physician and Alchemist

Al-Razi emphasized evidence-based medicine and direct clinical observation centuries before such approaches became central to modern scientific methodology. Al-Razi rejected blind adherence to earlier authorities and argued that physicians should prioritize careful observation of patients and clinical outcomes.

Al-Razi documented numerous neurological and psychological conditions, including paralysis, sensory dysfunction, cranial trauma, cognitive impairment, and mood disturbances. Importantly, he attempted to distinguish neurological disorders from psychiatric illnesses at a time when many societies continued interpreting such conditions primarily through supernatural or spiritual frameworks. His writings reflect an increasingly medicalized understanding of disorders affecting cognition and behavior.

IMAGE SOURCE: Abu Bakr Muhammad Ibn Zakariya Al Razi (Rhazes): Philosopher, Physician and Alchemist

In his clinical reports, he demonstrated an impressive ability to connect the location of a lesion in the nervous system with the symptoms a patient experienced. Developing an early form of applied neuroanatomy, using clinical signs to reason about where damage may have occurred in the body. His work also included descriptions of neurological conditions such as paralysis, sensory dysfunction, numbness, cranial trauma, headache, epilepsy, and cognitive impairment. He is credited with clearly distinguishing concussion from other neurological conditions.

Al-Razi was also significant in the history of mental healthcare. While serving as director of the main hospital in Baghdad, he established a special section for patients experiencing mental illness. He treated patients with respect, care, and empathy, and some accounts describe patients receiving money after discharge to help support their immediate needs. This represents one of the earliest recorded examples of psychiatric aftercare.

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“Absence of understanding does not warrant absence of existence” – Ibn Sina

IMAGE SOURCE: Ibn Sina’s The Canon of Medicine

This represented a profound conceptual shift away from earlier heart-centered theories inherited from portions of Greek and ancient medical traditions. He described epilepsy, stroke, vertigo, paralysis, tremors, traumatic brain injury, meningitis, and mood disorders with impressive clinical detail.

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Particularly significant were Ibn Sina’s theories regarding cognition and mental faculties. He proposed that different psychological processes, such as memory, imagination, reasoning, perception, and emotional interpretation, corresponded to distinct internal faculties associated with the brain. Although framed philosophically rather than neurologically, these theories resembled early forms of functional localization, the idea that different brain regions or systems specialize in different cognitive functions.

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His discussions of memory, imagination, perception, and sensory integration anticipated later conversations within cognitive neuroscience regarding distributed information processing and specialized neural systems. Ibn Sina also explored how emotional states could influence physical health, an idea that aligns surprisingly well with modern understandings of neuropsychiatry, psychosomatic medicine, and stress physiology.

IMAGE SOURCE: Ibn Sina’s The Canon of Medicine

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“If learning the truth is a scientist’s goal, then he must make himself the enemy of all that he reads” – Ibn al-Haytham

IMAGE SOURCE: Ibn Al Haytham Optics II – Life and Achievements

In his Book of Optics, Ibn al-Haytham challenged earlier Greek theories that suggested vision occurred because rays emanated outward from the eyes. Through experimentation involving mirrors, lenses, light refraction, and camera obscura principles, he demonstrated that vision occurred when light entered the eyes from external objects before being processed internally.

Diagram of the human visual system

IMAGE SOURCE: Ibn al-Haytham and the origins of modern image analysis

More importantly, Ibn al-Haytham’s work was revolutionary not only because of his theories of vision, but because of his insistence on experimentation itself. Rather than accepting inherited authority unquestioningly, he emphasized observation, testing, and evidence as necessary parts of scientific inquiry. Ibn al-Haytham argued that visual perception did not occur solely within the eyes themselves, but rather through interpretation within the brain. This distinction represented one of the earliest scientific frameworks connecting sensory input to cognitive processing. In many ways, his work laid conceptual foundations for sensory neuroscience, visual cognition, and the scientific study of perception.

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“The physician should not covet wealth, but serve out of compassion…” – Al-Zahrawi

His encyclopedia described surgical procedures involving skull fractures, cranial trauma, cauterization, spinal injuries, and neurological complications resulting from wounds or accidents. He designed numerous surgical instruments and emphasized careful anatomical knowledge, operative precision, and postoperative care. His work significantly influenced both Islamic and European surgery for centuries.

Illustration of Al-Zahrawi’s Surgical Instruments

IMAGE SOURCE: The “Father of Surgery” Abu al-Qasim al-Zahrawi

IMAGE SOURCE: The Islamic Roots of the Modern Hospital

IMAGE SOURCES: Al-Zahrawi replica instruments; Modern surgical instruments

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This holistic integration of medicine, psychology, philosophy, and caregiving became one of the defining characteristics of neuroscience during the Islamic Golden Age. Scholars did not sharply separate the mind from the body or cognition from physiology in the same way many later scientific traditions would. Instead, they approached consciousness, sensation, memory, emotion, and illness as interconnected phenomena requiring interdisciplinary understanding.

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Modern Neuroscience in the Region

A clear example of this can be seen in mathematics, which illustrates how scientific memory can be shaped by naming and power. Concepts often taught as if they emerged from Europe had deeper roots across the ancient and medieval Middle East. The relationship now called the Pythagorean theorem, for example, was known and used well before Pythagoras; Old Babylonian tablets such as Plimpton 322 contain Pythagorean triples more than a thousand years before the Greek tradition associated the theorem with his name. Similarly, the algebraic methods behind solving quadratic equations were systematized by Al-Khwarizmi, whose work on al-jabr helped give us the word “algebra,” yet students today usually learn the result as the impersonal “quadratic formula” rather than through his intellectual legacy. Even the binomial coefficients commonly arranged in “Pascal’s triangle” were studied centuries earlier by Islamic and Chinese mathematicians, including Al-Karaji and Omar Khayyam, before later European naming conventions became dominant. Erasure does not always happen by denying a discovery outright; sometimes it happens more quietly, when the names attached to knowledge obscure the civilizations and scholars who helped build it.

Yet these scientific traditions across the Middle East and North Africa continued to evolve, adapt, and persist through physicians, scholars, researchers, and healthcare workers into modernity. Understanding this continuity is essential for ensuring historical accuracy and continuing the task of decolonizing neuroscience itself.

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Although modern discussions of the region often begin with conflict, occupation, and instability, this framing risks overlooking the scientists, physicians, psychologists, and researchers who continue to produce knowledge across the Middle East today.

Across the region, researchers continue to work in fields such as neurogenetics, epilepsy, neurodegenerative disease, neurodevelopment, psychiatric neuroscience, computational neuroscience, trauma research, neuroengineering, and cognitive science. This scientific work matters because it challenges the assumption that knowledge primarily flows from Europe or North America outward into the rest of the world. In reality, neuroscience has always been shaped by many intellectual traditions, and the Middle East continues to be a site of scientific production rather than merely a site of scientific extraction.

For example, researchers throughout North Africa and the Middle East have contributed to studies of schizophrenia, mood disorders, neurodevelopmental disorders, epilepsy, Alzheimer’s disease, stroke, traumatic brain injury, and the genetic basis of neurological and psychiatric illness. This work is particularly important because much of neuroscience and psychiatric genetics still relies heavily on Western populations, limiting how well scientific conclusions can represent humanity as a whole. Expanding neuroscience research within Middle Eastern populations is therefore not only a regional concern but a global scientific necessity.

This is especially clear in Palestine.

Palestinian scientists, physicians, psychologists, psychiatrists, and healthcare workers continue producing knowledge and providing care despite severe structural barriers. Their work on childhood trauma, PTSD, emotional regulation, chronic stress, and stress-related neuropsychological outcomes demonstrates that Palestinians are not only subjects of trauma research but active contributors to scientific and clinical knowledge.

The Palestinian context also reveals how neuroscience intersects directly with occupation, colonialism, and structural violence. Chronic exposure to displacement, restricted movement, military violence, loss, uncertainty, and destruction of infrastructure can shape the nervous system through repeated activation of stress pathways. In children, especially, prolonged activation of the hypothalamic-pituitary-adrenal (HPA) axis may affect emotional regulation, memory processing, fear responses, executive functioning, and neurodevelopment.

Iraq offers another important example. Iraqi researchers and physicians continue working within healthcare systems shaped by decades of sanctions, invasion, insurgency, infrastructure collapse, and environmental contamination. Neuroscience research connected to Iraq increasingly involves PTSD, civilian trauma, neurodevelopment, environmental neurotoxicity, traumatic brain injury, and the long-term neurological consequences of war. This matters because Iraqi civilians remain underrepresented in global trauma neuroscience compared with Western military populations, even though Iraqi civilians have endured prolonged exposure to war and displacement. Your draft already identifies this imbalance as a power issue within scientific research.

Much of modern trauma neuroscience has historically centered on Western soldiers and veterans, while comparatively less attention has been given to civilians in countries where those wars were fought. Decolonizing trauma neuroscience means expanding the frame beyond military-centered research and asking how war affects children, families, caregivers, refugees, disabled civilians, and communities living with the long-term consequences of violence.

Doing so would repeat the very problem decolonial scholarship tries to challenge. The region’s modern neuroscience also includes work in clinical neurology, epilepsy treatment, psychiatric genetics, neurodevelopmental disorders, neurodegenerative disease, stroke rehabilitation, artificial intelligence, brain-computer interfaces, and computational approaches to brain research. The point is not that Middle Eastern neuroscience exists only because of conflict. The point is that scientific brilliance continues despite conflict, and that political violence often suppresses infrastructure without eliminating intellectual creativity.

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